Ferroptosis of CD163⁺ tissue-infiltrating macrophages and CD10⁺ PC⁺ epithelial cells in lupus nephritis.

ABSTRACT:

Background

Dysregulation of cell death and defective clearance of dying cells are closely related to the pathogenesis of lupus nephritis (LN). However, the contribution of a recently discovered form of programmed cell death (PCD) called ferroptosis to LN has not been explored in detail. The purpose of this study was to investigate the role of ferroptosis and its associated metabolic pathways in the pathogenesis of LN.

Methods

The composite gene expression scores were calculated by averaging the z-scored transformed log2 expressed genes within each form of PCD and pathway. Immunohistochemistry and immunofluorescence assays were used to verify the bioinformatics results.

Results

We determined that ferroptosis is prominently and specifically elevated in the glomerular co

SUBMITTER: Cheng Q 

PROVIDER: S-EPMC10423811 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature