Engagement of intrinsic disordered proteins in protein-protein interaction.

ABSTRACT: Proteins from the intrinsically disordered group (IDP) focus the attention of many researchers engaged in protein structure analysis. The main criteria used in their identification are lack of secondary structure and significant structural variability. This variability takes forms that cannot be identified in the X-ray technique. In the present study, different criteria were used to assess the status of IDP proteins and their fragments recognized as intrinsically disordered regions (IDRs). The status of the hydrophobic core in proteins identified as IDPs and in their complexes was assessed. The status of IDRs as components of the ordering structure resulting from the construction of the hydrophobic core was also assessed. The hydrophobic core is understood as a structure encompassing the e

SUBMITTER: Roterman I 

PROVIDER: S-EPMC10423874 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature