Identification of LOX as a candidate prognostic biomarker in Glioblastoma multiforme.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is the most malignant type of glioma. GBM tumors grow rapidly, have a high degree of malignancy, and are characterized by a fast disease progression. Unfortunately, there is a lack of effective treatments. An effective strategy for the treatment of GBM would be to identify key biomarkers correlating with the occurrence and progression of GBM and developing these biomarkers into therapeutic targets.

Method and results

In this study, using integrated bioinformatics analysis, we identified differentially expressed genes (DEGs), including 130 genes that were upregulated in GBM compared to normal brain tissue, and 128 genes that were downregulated in GBM. Based on Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genome

SUBMITTER: Liu E 

PROVIDER: S-EPMC10423882 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature