The effect of plasma cortisol on hippocampal atrophy and clinical progression in mild cognitive impairment

ABSTRACT: Abstract

Introduction

Both elevated cortisol and hippocampal volume have been linked to an increased risk for the development of Alzheimer's disease (AD). This longitudinal study assessed the effects of plasma cortisol on hippocampal atrophy and clinical progression rates in patients with mild cognitive impairment (MCI).

Methods

Patients with amnestic MCI (n = 304) were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) based on availability of baseline plasma cortisol and hippocampal volume measures, assessed at baseline and during follow‐ups. We investigated associations between plasma cortisol, hippocampal volume, and risk of clinical progression to AD over a study period of up to 100 months (mean follow‐up time 36.8 months) using linear mixed models,

SUBMITTER: White S 

PROVIDER: S-EPMC10423926 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature