Evaluation of the role of FMR1 CGG repeat allele in Parkinson's disease from the Chinese population.

ABSTRACT:

Objective

There is controversial evidence that FMR1 premutation or "gray zone" (GZ) allele (small CGG expansion, 45-54 repeats) was associated with Parkinson's disease (PD). We aimed to explore further the association between FMR1 CGG repeat expansions and PD in a large sample of Chinese origin.

Methods

We included a cohort of 2,362 PD patients and 1,072 controls from the Parkinson's Disease and Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC) in this study and conducted repeat-primed polymerase chain reaction (RP-PCR) for the size of FMR1 CGG repeat expansions.

Results

Two PD patients were detected with FMR1 premutation (61 and 56 repeats), and the other eleven PD patients were detected with the GZ alle

SUBMITTER: Chen J 

PROVIDER: S-EPMC10423993 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature