Identification of functional genes regulating gastric cancer progression using integrated bioinformatics analysis.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common cancers and has a poor prognosis. Treatment of GC has remained unchanged over the past few years.

Aim

To investigate the potential therapeutic targets and related regulatory biomarkers of GC.

Methods

We obtained the public GC transcriptome sequencing dataset from the Gene Expression Omnibus database. The datasets contained 348 GC tissues and 141 healthy tissues. In total, 251 differentially expressed genes (DEGs) were identified, including 187 down-regulated genes and 64 up-regulated genes. The DEGs' enriched functions and pathways include Progesterone-mediated oocyte maturation, cell cycle, and oocyte meiosis, Hepatitis B, and the Hippo signaling pathway. Survival analysis showed that BUB1, MAD2L1, CCNA2, CCNB1

SUBMITTER: Yu K 

PROVIDER: S-EPMC10424021 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature