A pharmacokinetic model of antiseizure medication load to guide care in the epilepsy monitoring unit.

ABSTRACT:

Objective

Evaluating patients with drug-resistant epilepsy often requires inducing seizures by tapering antiseizure medications (ASMs) in the epilepsy monitoring unit (EMU). The relationship between ASM taper strategy, seizure timing, and severity remains unclear. In this study, we developed and validated a pharmacokinetic model of total ASM load and tested its association with seizure occurrence and severity in the EMU.

Methods

We studied 80 patients who underwent intracranial electroencephalographic recording for epilepsy surgery planning. We developed a first order pharmacokinetic model of the ASMs administered in the EMU to generate a continuous metric of overall ASM load. We then related modeled ASM load to seizure likelihood and severity. We determined the association

SUBMITTER: Ghosn NJ 

PROVIDER: S-EPMC10424095 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature