The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves' Orbitopathy.

ABSTRACT:

Purpose

Graves' orbitopathy (GO) is an orbital manifestation of autoimmune Graves' disease, and orbital fibroblast is considered a target cell, producing pro-inflammatory cytokines and/or differentiating into adipocytes. Adipose tissue has been focused on as an endocrine and inflammatory organ secreting adipokines. We investigated the pathogenic role of a specific adipokine, adipsin, known as complement factor D in Graves' orbital fibroblasts.

Methods

The messenger RNA (mRNA) expression of multiple adipokines was investigated in adipose tissues harvested from GO and healthy subjects. Adipsin protein production was analyzed in primary cultured orbital fibroblasts under insulin growth factor (IGF)-1, CD40 ligand (CD40L) stimulation, and adipogenesis. The effect of blocking adi

SUBMITTER: Byeon HJ 

PROVIDER: S-EPMC10424154 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature