Ontology highlight
ABSTRACT:
SUBMITTER: Berwanger A
PROVIDER: S-EPMC10424179 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Berwanger Aylin A Stein Saskia C SC Kany Andreas M AM Gartner Melissa M Loretz Brigitta B Lehr Claus-Michael CM Hirsch Anna K H AKH Schulz Thomas F TF Empting Martin M
Journal of medicinal chemistry 20230728 15
Kaposi's sarcoma-associated herpesvirus (KSHV) can establish latent lifelong infections in infected individuals. During viral latency, the latency-associated nuclear antigen (LANA) mediates the replication of the latent viral genome in dividing cells and tethers them to mitotic chromosomes, thus ensuring their partitioning into daughter cells during mitosis. This study aims to inhibit Kaposi's sarcoma-associated herpesvirus (KSHV) latent replication by targeting the LANA-DNA interaction using sm ...[more]