Beyond Stereoisomeric Effects: Exploring the Importance of Intermolecular Electron Spin Interactions in Biorecognition.

ABSTRACT: This work shows that electron spin polarization and stereoisomeric effects make comparable contributions to the enantioselective binding of amino acids. Magneto-electrochemical quartz crystal microbalance methods are used to study the adsorption of chiral amino acids onto a monolayer film of chiral molecules that are spin polarized by an underlying ferromagnetic substrate. The direction of the electron spin polarization affects both the kinetics and thermodynamics of the enantiospecific adsorption of the amino acids. Comparison of these data with the circular dichroism (CD) spectra of the amino acid adsorbates shows that the CD spectrum of the interacting group provides a good figure-of-merit for predicting the contributions of electron spin to the intermolecular interaction. These finding

SUBMITTER: Lu Y 

PROVIDER: S-EPMC10424231 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature