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A concise review on the role of MIR100HG in human disorders.

ABSTRACT: MIR100HG is a long non-coding RNA (lncRNA) encoded by a locus on chr11:122,028,203-122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF-β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in a diversity of cancers in association with clinical outcomes. Moreover, it has a role in the pathophysiology of dilated cardiomyopathy, intervertebral disk degeneration and pulmonary fibrosis. The current study summarizes the role of these lncRNAs in human disorders.

SUBMITTER: Ghafouri-Fard S

PROVIDER: S-EPMC10424294 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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A concise review on the role of MIR100HG in human disorders.

Ghafouri-Fard Soudeh S Harsij Atefeh A Farahzadi Hossein H Hussen Bashdar Mahmud BM Taheri Mohammad M Mokhtari Majid M

Journal of cellular and molecular medicine 20230724 16

MIR100HG is a long non-coding RNA (lncRNA) encoded by a locus on chr11:122,028,203-122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF-β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in ...[more]

PMID: 37487022

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