Gut microbiota and intervertebral disc degeneration: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Although previous studies have suggested a close association between gut microbiota (GM) and intervertebral disc degeneration (IVDD), the causal relationship between them remains unclear. Hence, we thoroughly investigate their causal relationship by means of a two-sample Mendelian randomization (MR) study, aiming to determine the impact of gut microbiota on the risk of developing intervertebral disc degeneration.

Methods

Summary data from genome-wide association studies of GM (the MiBioGen) and IVDD (the FinnGen biobank) have been acquired. The inverse variance weighted (IVW) method was utilized as the primary MR analysis approach. Weighted median, MR-Egger regression, weighted mode, and simple mode were used as supplements. The Mendelian randomization pleiotropy

SUBMITTER: Geng Z 

PROVIDER: S-EPMC10424333 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature