Current views on meningeal lymphatics and immunity in aging and Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is an aging-related form of dementia associated with the accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the brain. These phenomena are accompanied by exacerbated inflammation and marked neuronal loss, which altogether contribute to accelerated cognitive decline. The multifactorial nature of AD, allied to our still limited knowledge of its etiology and pathophysiology, have lessened our capacity to develop effective treatments for AD patients. Over the last few decades, genome wide association studies and biomarker development, alongside mechanistic experiments involving animal models, have identified different immune components that play key roles in the modulation of brain pathology in AD, affecting its progression and sever

SUBMITTER: Rego S 

PROVIDER: S-EPMC10424377 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature