Causal effects between atrial fibrillation and heart failure: evidence from a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested a close association between atrial fibrillation (AF) and heart failure (HF), yet the causal effect remains uncertain. In this study, we employed a bidirectional Mendelian randomization analysis to investigate the causal effect of one disease on the other.

Methods

Genetic instrumental variables were obtained from large-scale summary-level genome-wide association studies of AF (n = 1,030,836) and HF(n = 1,665,481), respectively. Two-sample Mendelian randomization was conducted to establish causal inferences. Inverse-variance weighted (IVW) was the primary estimate, while additional analyses including MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), MR-Egger, and Weighted median were performed to validate robustness and identif

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10424396 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature