Defining aggressive prostate cancer: a geospatial perspective.

ABSTRACT:

Background

Spatial analysis can identify communities where men are at risk for aggressive prostate cancer (PCan) and need intervention. However, there are several definitions for aggressive PCan. In this study, we evaluate geospatial patterns of 3 different aggressive PCan definitions in relation to PCan-specific mortality and provide methodologic and practical insights into how each definition may affect intervention targets.

Methods

Using the Pennsylvania State Cancer Registry data (2005-2015), we used 3 definitions to assign "aggressive" status to patients diagnosed with PCan. Definition one (D1, recently recommended as the primary definition, given high correlation with PCan death) was based on staging criteria T4/N1/M1 or Gleason score ≥ 8. Definition two (D2, most freq

SUBMITTER: Wiese D 

PROVIDER: S-EPMC10424402 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature