Ultrasound-based radiomics model for predicting molecular biomarkers in breast cancer

ABSTRACT:

Background

Breast cancer (BC) is the most common cancer in women and is highly heterogeneous. BC can be classified into four molecular subtypes based on the status of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and proliferation marker protein Ki-67. However, they can only be obtained by biopsy or surgery, which is invasive. Radiomics can noninvasively predict molecular expression via extracting the image features. Nevertheless, there is a scarcity of data available regarding the prediction of molecular biomarker expression using ultrasound (US) images in BC.

Objectives

To investigate the prediction performance of US radiomics for the assessment of molecular profiling in BC.

Methods

A total of 342 patients w

SUBMITTER: Xu R 

PROVIDER: S-EPMC10424446 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature