Mitochondrial Ca²⁺ homeostasis in trypanosomes.

ABSTRACT: Mitochondrial calcium ion (Ca²⁺) uptake is important for buffering cytosolic Ca²⁺ levels, for regulating cell bioenergetics, and for cell death and autophagy. Ca²⁺ uptake is mediated by a mitochondrial Ca²⁺ uniporter (MCU) and the discovery of this channel in trypanosomes has been critical for the identification of the molecular nature of the channel in all eukaryotes. However, the trypanosome uniporter, which has been studied in detail in Trypanosoma cruzi, the agent of Chagas disease, and T. brucei, the agent of human and animal African trypanosomiasis, has lineage-specific adaptations which include the lack of some homologues to mammalian subunits, and the presence of unique subunits. Here, we review newly emerging insights into the role of mi

SUBMITTER: Docampo R 

PROVIDER: S-EPMC10424509 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature