Combined proteomics and transcriptomics identifies serpin family C member 1 associated protein as a biomarker of endometriosis.

ABSTRACT:

Objective

To explore potential biomarkers indicating endometriosis (EM).

Materials and methods

A proteomics method and combined quantitative transcriptomics were adopted to highlight markers in the EM. Venn analysis was used to integrate the ribonucleic acid sequencing (RNA-seq) and protein profiles. Promising candidate markers were tested by enzyme-related immunosorbent assay.

Results

A sum of 979 mRNAs and 39 proteins were tested to be significantly differentially expression in the standard cluster compared with the EM cluster. Venn analysis showed a filtered signature of only two down-regulated molecules in the EM group, i.e. fetuin B (FETUB) and serpin family C member 1 (SERPINC1); the latter showed a big variance between the control category and the EM set in the

SUBMITTER: Li XY 

PROVIDER: S-EPMC10424617 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature