Distinct cerebral small vessel disease impairment in early- and late-onset Alzheimer's disease.

ABSTRACT:

Objective

This study investigated cerebral small vessel disease (CSVD) damage patterns in early-onset and late-onset Alzheimer's disease (EOAD and LOAD) and their effects on cognitive function.

Methods

This study included 93 participants, 45 AD patients (14 EOAD and 31 LOAD), and 48 normal controls (13 YNC and 35 ONC) from the ADNI database. All participants had diffusion tensor imaging data; some had amyloid PET and plasma p-tau₁₈₁ data. The study used peak width of skeletonized mean diffusivity (PSMD) to measure CSVD severity and compared PSMD between patients and age-matched controls. The effect of age on the relationship between PSMD and cognition was also examined. The study also repeated the analysis in amyloid-positive AD patients and amyloid-negative contr

SUBMITTER: Luo X 

PROVIDER: S-EPMC10424647 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature