Increased plasma levels of circPTP4A2 and circTLK2 are associated with stroke injury.

ABSTRACT:

Objective

Accumulating studies have shown that circulating circular RNAs (circRNAs) represent novel biomarkers for many human diseases. We investigated whether plasma circPTP4A2 and circTLK2 levels are associated with stroke severity, infarct volume, stroke etiology, and functional outcome in acute ischemic stroke (AIS) patients.

Methods

We applied quantitative real-time PCR (qPCR) to measure plasma circPTP4A2 and circTLK2 levels of 236 AIS patients within 72 h of symptoms onset and 136 healthy controls. We further assessed the National Institutes of Health Stroke Scale (NIHSS), infarct size, the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification and the 90-day modified Rankin scale (mRS) for each patient.

Results

At admission, plasma circPTP4A2 and c

SUBMITTER: Wang X 

PROVIDER: S-EPMC10424654 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature