Biomarkers in cerebrospinal fluid for amyotrophic lateral sclerosis phenotypes.

ABSTRACT:

Objective

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower motor neurons. The motor phenotypes of ALS are highly clinically heterogeneous, and the underlying mechanisms are poorly understood.

Methods

A comparative proteomic analysis was performed in the cerebrospinal fluid (CSF) of bulbar-onset (BO) and spinal-onset (SO) ALS patients and controls (n = 14). Five biomarker candidates were selected from a differentially regulated protein pool, and further validation was performed in a larger independent cohort (n = 92) using enzyme-linked immunosorbent assay (ELISA).

Results

A total of 1732 CSF proteins were identified, and 78 differentially expressed proteins were found among BO-ALS patients, SO-ALS patients,

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10424661 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature