Surfaceome Profiling Identifies Basigin-Chaperoned Protein Clients.

ABSTRACT: The surface proteome or "surfaceome" is a critical mediator of cellular biology, facilitating cell-to-cell interactions and communication with extracellular biomolecules. Constituents of the surfaceome can serve as biomarkers for changing cell states and as targets for pharmacological intervention. While some pathways of cell surface trafficking are well characterized to allow prediction of surface localization, some non-canonical trafficking mechanisms do not. Basigin (Bsg), a cell surface glycoprotein, has been shown to chaperone protein clients to the cell surface. However, understanding which proteins are served by Bsg is not always straightforward. To accelerate such identification, we applied a surfaceome proximity labeling method that is integrated with quantitative mass spectrometr

SUBMITTER: Vilen Z 

PROVIDER: S-EPMC10424708 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature