Electrostatically assembled wound dressings deliver pro-angiogenic anti-miRs preferentially to endothelial cells.

ABSTRACT: Chronic non-healing wounds occur frequently in individuals affected by diabetes, yet standard-of-care treatment leaves many patients inadequately treated or with recurring wounds. MicroRNA (miR) expression is dysregulated in diabetic wounds and drives an anti-angiogenic phenotype, but miRs can be inhibited with short, chemically-modified RNA oligonucleotides (anti-miRs). Clinical translation of anti-miRs is hindered by delivery challenges such as rapid clearance and uptake by off-target cells, requiring repeated injections, excessively large doses, and bolus dosing mismatched to the dynamics of the wound healing process. To address these limitations, we engineered electrostatically assembled wound dressings that locally release anti-miR-92a, as miR-92a is implicated in angiogenesis and wou

SUBMITTER: Berger AG 

PROVIDER: S-EPMC10424785 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature