Genetic Correlations Among Corneal Biophysical Parameters and Anthropometric Traits.

ABSTRACT:

Purpose

The genetic architecture of corneal dysfunction remains poorly understood. Epidemiological and clinical evidence suggests a relationship between corneal structural features and anthropometric measures. We used global and local genetic similarity analysis to identify genomic features that may underlie structural corneal dysfunction.

Methods

We assembled genome-wide association study summary statistics for corneal features (central corneal thickness, corneal hysteresis [CH], corneal resistance factor [CRF], and the 3 mm index of keratometry) and anthropometric traits (body mass index, weight, and height) in Europeans. We calculated global genetic correlations (rg) between traits using linkage disequilibrium (LD) score regression and local genetic covariance using ρ-HES

SUBMITTER: Cousins HC 

PROVIDER: S-EPMC10424803 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature