Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry.

ABSTRACT:

Background

Genetic factors play an important role in prostate cancer (PCa) susceptibility.

Objective

To discover common genetic variants contributing to the risk of PCa in men of African ancestry.

Design, setting, and participants

We conducted a meta-analysis of ten genome-wide association studies consisting of 19378 cases and 61620 controls of African ancestry.

Outcome measurements and statistical analysis

Common genotyped and imputed variants were tested for their association with PCa risk. Novel susceptibility loci were identified and incorporated into a multiancestry polygenic risk score (PRS). The PRS was evaluated for associations with PCa risk and disease aggressiveness.

Results and limitations

Nine novel susceptibility loci for PCa were identifie

SUBMITTER: Chen F 

PROVIDER: S-EPMC10424812 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature