Adipose derived stromal vascular fraction and fat graft for treating the hands of patients with systemic sclerosis. A randomized clinical trial.

ABSTRACT:

Background

Systemic Sclerosis in the hand is characteristically evidenced by Raynaud's phenomenon, fibrosis of the skin, tendons, ligaments, and joints as well as digital ulcers with prolonged healing. Current medical treatment does not always cure these complications. Local adipose-derived stromal vascular fraction administration into the hands has been proposed as an emerging treatment due to its regenerative properties. The objective of this randomized controlled clinical trial was to evaluate the safety and clinical effects of fat micrografts plus adipose derived-stromal vascular fraction administration into the hands of patients with systemic sclerosis.

Methods

This was an open-label, monocentric, randomized controlled study. Twenty patients diagnosed with systemic scle

SUBMITTER: Iglesias M 

PROVIDER: S-EPMC10424873 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature