Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization

ABSTRACT:

Introduction

The correlation between dyslipidemia and periodontitis is revealed through epidemiological studies. However, the results are affected by several confounding factors. This study aims to elucidate the genetic causal association between circulating lipid traits and periodontitis by two-sample Mendelian randomization (MR) analysis.

Methods

After the different screening processes, two cohorts of circulating lipid traits from the UK Biobank were used as exposure data, including five circulating lipid traits. The Periodontitis cohort was selected from the GeneLifestyle Interactions in Dental Endpoints (GLIDE) consortium as outcome data. In univariable MR, the inverse variance weighted (IVW) was used in conjunction with six additional analytical methods to assess cau

SUBMITTER: Hu G 

PROVIDER: S-EPMC10424932 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature