Measuring human cerebral blood flow and brain function with fiber-based speckle contrast optical spectroscopy system.

ABSTRACT: Cerebral blood flow (CBF) is crucial for brain health. Speckle contrast optical spectroscopy (SCOS) is a technique that has been recently developed to measure CBF, but the use of SCOS to measure human brain function at large source-detector separations with comparable or greater sensitivity to cerebral rather than extracerebral blood flow has not been demonstrated. We describe a fiber-based SCOS system capable of measuring human brain activation induced CBF changes at 33 mm source detector separations using CMOS detectors. The system implements a pulsing strategy to improve the photon flux and uses a data processing pipeline to improve measurement accuracy. We show that SCOS outperforms the current leading optical modality for measuring CBF, i.e. diffuse correlation spectroscopy (DCS), ach

SUBMITTER: Kim B 

PROVIDER: S-EPMC10425329 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature