Phylobone: a comprehensive database of bone extracellular matrix proteins in human and model organisms.

ABSTRACT: The bone extracellular matrix (ECM) contains minerals deposited on highly crosslinked collagen fibrils and hundreds of non-collagenous proteins. Some of these proteins are key to the regulation of bone formation and regeneration via signaling pathways, and play important regulatory and structural roles. However, the complete list of bone extracellular matrix proteins, their roles, and the extent of individual and cross-species variations have not been fully captured in both humans and model organisms. Here, we introduce the most comprehensive resource of bone extracellular matrix (ECM) proteins that can be used in research fields such as bone regeneration, osteoporosis, and mechanobiology. The Phylobone database (available at https://phylobone.com ) includes 255 proteins potentially expres

SUBMITTER: Fontcuberta-Rigo M 

PROVIDER: S-EPMC10425349 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature