Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis.

ABSTRACT: Liver cancer is one of the most lethal malignancies with an annual death of over 830,000 cases. Although targeted therapeutic drugs have achieved certain clinical efficacy, only sorafenib and lenvatinib are currently marketed as first-line targeted drugs to treat patients with advanced liver cancer. Therefore, developing more drugs are urgently needed. Ferroptosis is an iron-dependent programmed cell death (PCD) distinct from known PCDs including apoptosis, necrosis, and autophagy. Targeting ferroptosis is recognized as a promising potential therapeutic modality for liver cancer. Activating transcription factor 3 (ATF3) is an important ferroptosis inducer and targeting ATF3 offers a potential means to cancer therapy. In the present study, we reported for the first time a sophoridine deriva

SUBMITTER: Tian K 

PROVIDER: S-EPMC10425377 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature