Identification of gene function based on models capturing natural variability of Arabidopsis thaliana lipid metabolism.

ABSTRACT: Lipids play fundamental roles in regulating agronomically important traits. Advances in plant lipid metabolism have until recently largely been based on reductionist approaches, although modulation of its components can have system-wide effects. However, existing models of plant lipid metabolism provide lumped representations, hindering detailed study of component modulation. Here, we present the Plant Lipid Module (PLM) which provides a mechanistic description of lipid metabolism in the Arabidopsis thaliana rosette. We demonstrate that the PLM can be readily integrated in models of A. thaliana Col-0 metabolism, yielding accurate predictions (83%) of single lethal knock-outs and 75% concordance between measured transcript and predicted flux changes under extended darkness. Genome-wide asso

SUBMITTER: Cordoba SC 

PROVIDER: S-EPMC10425450 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature