Mechanical hierarchy in the formation and modulation of cortical folding patterns.

ABSTRACT: The important mechanical parameters and their hierarchy in the growth and folding of the human brain have not been thoroughly understood. In this study, we developed a multiscale mechanical model to investigate how the interplay between initial geometrical undulations, differential tangential growth in the cortical plate, and axonal connectivity form and regulate the folding patterns of the human brain in a hierarchical order. To do so, different growth scenarios with bilayer spherical models that features initial undulations on the cortex and uniform or heterogeneous distribution of axonal fibers in the white matter were developed, statistically analyzed, and validated by the imaging observations. The results showed that the differential tangential growth is the inducer of cortical foldin

SUBMITTER: Chavoshnejad P 

PROVIDER: S-EPMC10425471 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature