Ontology highlight
ABSTRACT:
SUBMITTER: Persico M
PROVIDER: S-EPMC10425525 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Persico Marco M Sessa Raffaele R Cesaro Elena E Dini Irene I Costanzo Paola P Ritieni Alberto A Fattorusso Caterina C Grosso Michela M
Cell biology and toxicology 20220906 4
Aflatoxin B1 (AFB1), produced by fungi of the genus Aspergillus, is the most toxic and carcinogenic mycotoxin among the classes of aflatoxins. Previous research showed that AFB1 affects vitamin D receptor (VDR) expression. In the present study, integrated computational and experimental studies were carried out to investigate how AFB1 can interfere with Vitamin D signalling. A competitive antagonism of AFB1 toward RXRα and VDR was hypothesized by comparing the docked complex of AFB1/RXRα and AFB1 ...[more]