Zika virus spreads through infection of lymph node-resident macrophages.

ABSTRACT: To disseminate through the body, Zika virus (ZIKV) is thought to exploit the mobility of myeloid cells, in particular monocytes and dendritic cells. However, the timing and mechanisms underlying shuttling of the virus by immune cells remains unclear. To understand the early steps in ZIKV transit from the skin, at different time points, we spatially mapped ZIKV infection in lymph nodes (LNs), an intermediary site en route to the blood. Contrary to prevailing hypotheses, migratory immune cells are not required for the virus to reach the LNs or blood. Instead, ZIKV rapidly infects a subset of sessile CD169⁺ macrophages in the LNs, which release the virus to infect downstream LNs. Infection of CD169⁺ macrophages alone is sufficient to initiate viremia. Overall, our experi

SUBMITTER: Reynoso GV 

PROVIDER: S-EPMC10425566 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature