Traumatic brain injury induces an adaptive immune response in the meningeal transcriptome that is amplified by aging.

ABSTRACT: Traumatic Brain Injury (TBI) is a major cause of disability and mortality, particularly among the elderly, yet our mechanistic understanding of how age renders the post-traumatic brain vulnerable to poor clinical outcomes and susceptible to neurological disease remains poorly understood. It is well established that dysregulated and sustained immune responses contribute to negative outcomes after TBI, however our understanding of the interactions between central and peripheral immune reservoirs is still unclear. The meninges serve as the interface between the brain and the immune system, facilitating important bi-directional roles in healthy and disease settings. It has been previously shown that disruption of this system exacerbates inflammation in age related neurodegenerative disorders s

SUBMITTER: Buenaventura RG 

PROVIDER: S-EPMC10425597 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature