Identification of KNOP1 as a prognostic marker in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a malignancy with a poor prognosis. This study aimed to evaluate the role and molecular mechanism of lysine-rich nucleolar protein 1 (KNOP1) in HCC.

Methods

Data from The Cancer Genome Atlas (TCGA), genotype-tissue expression (GTEx), and Gene Expression Omnibus (GEO) databases were used to compare KNOP1 expression in normal and HCC tissues. The Human Protein Atlas (HPA) database was used to verify KNOP1 protein expression. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), gene set enrichment, protein-protein and gene-gene interaction network, DNA methylation, genetic alteration, and immune cell infiltration analyses were used to analyze the function and pathway enrichment of KNOP1. Finally, r

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10425640 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature