Identification and validation of a novel prognostic model for gastric cancer based on m7G-related genes.

ABSTRACT:

Background

The role of N7-methyladenosine (m7G)-related genes in the progression and prognosis of gastric cancer (GC) remains unclear. This study aimed to explore prognostic biomarkers for GC based on m7G methylation regulators and to construct a prognostic risk model.

Methods

RNA sequencing profiles with corresponding clinicopathological information associated with GC of which the histological type was stomach adenocarcinoma (STAD) were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), respectively. A total of 29 m7G regulators were extracted from previous studies. According to the expression similarity of m7G regulators, the GC samples obtained from TCGA were further classified into 2 clusters demonstrating different overall survival (OS) rate

SUBMITTER: Deng K 

PROVIDER: S-EPMC10425669 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature