Alteration of the leptin network in late morbid obesity induced in mice by brain infection with canine distemper virus.

ABSTRACT: Viruses can induce progressive neurologic disorders associated with diverse pathological manifestations, and therefore, viral infection of the brain can impair differentiated neural functions, depending on the initial viral tropism. We have previously reported that canine distemper virus (CDV) targets certain mouse brain structures, including the hypothalamus, early and selectively. Infected mice exhibit acute encephalitis, with late disease, characterized by motor impairment or obesity syndrome, appearing in some of the surviving mice several months after the initial viral replication. In the present study, we show viral persistence in the hypothalami of obese mice, as demonstrated by low, but still significant, levels of CDV nucleoprotein transcripts, associated with a dramatic decrease

SUBMITTER: Bernard A 

PROVIDER: S-EPMC104257 | biostudies-literature | 1999 Sep

REPOSITORIES: biostudies-literature