RNA m⁶A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression.

ABSTRACT: As the most common internal modification of mRNA, N⁶-methyladenosine (m⁶A) and its regulators modulate gene expression and play critical roles in various biological and pathological processes including tumorigenesis. It was reported previously that m⁶A methyltransferase (writer), methyltransferase-like 3 (METTL3) adds m⁶A in primary microRNAs (pri-miRNAs) and facilitates its processing into precursor miRNAs (pre-miRNAs). However, it is unknown whether m⁶A modification also plays a role in the maturation process of pre-miRNAs and (if so) whether such a function contributes to tumorigenesis. Here, we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia (AML) patients, especially in relapsed patients, and plays a

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10425806 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature