Phytoestrogen-derived multifunctional ligands for targeted therapy of breast cancer.

ABSTRACT: Nano-targeted delivery systems have been widely used for breast tumor drug delivery. Estrogen receptors are considered to be significant drug delivery target receptors due to their overexpression in a variety of tumor cells. However, targeted ligands have a significant impact on the safety and effectiveness of active delivery systems, limiting the clinical transformation of nanoparticles. Phytoestrogens have shown good biosafety characteristics and some affinity with the estrogen receptor. In the present study, molecular docking was used to select tanshinone IIA (Tan IIA) among phytoestrogens as a target ligand to be used in nanodelivery systems with some modifications. Modified Tan IIA (Tan-NH₂) showed a good biosafety profile and demonstrated tumor-targeting, anti-tumor and an

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10425851 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature