Proton Pump Inhibitor Use and Risk of Serious Infections in Young Children.

ABSTRACT:

Importance

Proton pump inhibitor (PPI) use may lead to infections through alteration of the microbiota or direct action on the immune system. However, only a few studies were conducted in children, with conflicting results.

Objective

To assess the associations between PPI use and serious infections in children, overall and by infection site and pathogen.

Design, setting, and participants

This nationwide cohort study was based on the Mother-Child EPI-MERES Register built from the French Health Data System (SNDS). We included all children born between January 1, 2010, and December 31, 2018, who received a treatment for gastroesophageal reflux disease or other gastric acid-related disorders, namely PPIs, histamine 2 receptor antagonists, or antacids/alginate. The index d

SUBMITTER: Lassalle M 

PROVIDER: S-EPMC10425862 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature