Optimal timing for local ablative treatment of bone oligometastases in non-small cell lung cancer.

ABSTRACT: Oligometastases is a term commonly used to describe a disease state characterized by a limited number of distant metastases, and represents a transient phase between localized and widespread systemic diseases. This subgroup of stage IV cancer has increased in clinical importance due to the possibility of curative rather than palliative treatment. Among advanced lung cancer patients, 30-40% show bone metastases, and can show complications such as pathological fractures. Many prospective studies have shown efficacy of localized treatment in oligometastatic non-small cell lung cancer (NSCLC) in improving progression-free survival and overall survival. Compared to metastases in other organs, bone metastases are unique in terms of tumor microenvironment and clinical outcomes. Radiotherapy is th

SUBMITTER: Lee J 

PROVIDER: S-EPMC10425942 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature