Impaired Abcb1a function and red meat in a translational colitis mouse model induces inflammation and alters microbiota composition.

ABSTRACT: Inflammatory Bowel Disease (IBD) affects approximately 0.3% of the global population, with incidence rates rising dramatically worldwide. Emerging evidence points to an interplay between exposome factors such as diet and gut microbiota, host genetics, and the immune system as crucial elements in IBD development. ATP-binding cassette (ABC) transporters, including human p-glycoprotein encoded by the Abcb1 gene, influence intestinal inflammation, and their expression may interact with environmental factors such as diet and gut microbes. Our study aimed to examine the impact of protein sources on a genetic colitis mouse model.

Methods

Abcb1a-deficient colitis mice were fed either casein or red meat-supplemented diets to investigate potential colitis-aggravating components in red meat an

SUBMITTER: Stensballe A 

PROVIDER: S-EPMC10425965 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature