De novo evolution of macroscopic multicellularity.

ABSTRACT: While early multicellular lineages necessarily started out as relatively simple groups of cells, little is known about how they became Darwinian entities capable of sustained multicellular evolution^1-3. Here we investigate this with a multicellularity long-term evolution experiment, selecting for larger group size in the snowflake yeast (Saccharomyces cerevisiae) model system. Given the historical importance of oxygen limitation⁴, our ongoing experiment consists of three metabolic treatments⁵-anaerobic, obligately aerobic and mixotrophic yeast. After 600 rounds of selection, snowflake yeast in the anaerobic treatment group evolved to be macroscopic, becoming around 2 × 10⁴ times larger (approximately mm scale) and about 10⁴-fold more b

SUBMITTER: Bozdag GO 

PROVIDER: S-EPMC10425966 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature