Host, reproductive, and lifestyle factors in relation to quantitative histologic metrics of the normal breast.

ABSTRACT:

Background

Emerging data indicate that variations in quantitative epithelial and stromal tissue composition and their relative abundance in benign breast biopsies independently impact risk of future invasive breast cancer. To gain further insights into breast cancer etiopathogenesis, we investigated associations between epidemiological factors and quantitative tissue composition metrics of the normal breast.

Methods

The study participants were 4108 healthy women ages 18-75 years who voluntarily donated breast tissue to the US-based Susan G. Komen Tissue Bank (KTB; 2008-2019). Using high-accuracy machine learning algorithms, we quantified the percentage of epithelial, stromal, adipose, and fibroglandular tissue, as well as the proportion of fibroglandular tissue that is epith

SUBMITTER: Abubakar M 

PROVIDER: S-EPMC10426057 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature