Fibroblast-to-cardiomyocyte lactate shuttle modulates hypertensive cardiac remodelling.

ABSTRACT:

Background

Cardiac fibroblasts (CFs) and cardiomyocytes are the major cell populations in the heart. CFs not only support cardiomyocytes by producing extracellular matrix (ECM) but also assimilate myocardial nutrient metabolism. Recent studies suggest that the classical intercellular lactate shuttle may function in the heart, with lactate transported from CFs to cardiomyocytes. However, the underlying mechanisms regarding the generation and delivery of lactate from CFs to cardiomyocytes have yet to be explored.

Results

In this study, we found that angiotensin II (Ang II) induced CFs differentiation into myofibroblasts that, driven by cell metabolism, then underwent a shift from oxidative phosphorylation to aerobic glycolysis. During this metabolic conversion, the expression

SUBMITTER: Wei T 

PROVIDER: S-EPMC10426103 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature