Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis.

ABSTRACT:

Background

Grade 4 glioma is the most aggressive and currently incurable brain tumor with a median survival of one year in adult patients. Elucidating novel transcriptomic and epigenetic contributors to the molecular heterogeneity underlying its aggressiveness may lead to improved clinical outcomes.

Methods

To identify grade 4 glioma -associated 5-hydroxymethylcytosine (5hmC) and transcriptomic features as well as their cross-talks, genome-wide 5hmC and transcriptomic profiles of tissue samples from 61 patients with grade 4 gliomas and 9 normal controls were obtained for differential and co-regulation/co-modification analyses. Prognostic models on overall survival based on transcriptomic features and the 5hmC modifications summarized over genic regions (promoters, gene bodie

SUBMITTER: Zeng C 

PROVIDER: S-EPMC10426201 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature