Identification of lysosome-related genes in connection with prognosis and immune cell infiltration for drug candidates in head and neck cancer

ABSTRACT: Abstract Lysosome dysfunction has been shown to play an important role in cancer progression. However, few research studies have reported the role of lysosomes in head and neck squamous cell carcinoma (HNSCC) progression. Lysosome-related genes (LRGs) were collected from the Molecular Signatures Database. Differentially expressed lysosome-related genes (DELRGs) were identified from the TCGA-HNSCC dataset. The least absolute shrinkage and selection operator and multivariate Cox regression analysis were used to identify the prognostic genes. The prognostic values and expression of hub DELRGs were further validated by GEO datasets. Estimation of STromal and Immune cells in MAlignant Tumors using Expression data and the single-sample gene set enrichment analysis were applied to evaluate the co

SUBMITTER: Shen Y 

PROVIDER: S-EPMC10426727 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature