Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder.

ABSTRACT:

Background

The hyperarousal process model plays a central role in the physiology of chronic insomnia disorder (CID). Recent evidence has demonstrated that the habenula is involved in the arousal and sleep-wake cycle. However, whether the intrinsic habenular functional network contributes to the underlying mechanism of CID and its relationship to the arousal state in CID remains unclear.

Methods

This single-centered study included 34 patients with subjective CID and 22 matched good sleep control (GSC), and underwent a series of neuropsychological tests and resting-state functional magnetic resonance imaging scans. The habenular functional network was assessed using seed-based functional connectivity (FC) analysis. The subjective arousal state was evaluated with the hyperarous

SUBMITTER: Gong L 

PROVIDER: S-EPMC10426801 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature