Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine.

ABSTRACT:

Background

Selective serotonin reuptake inhibitors such as fluoxetine have a limited treatment efficacy. The mechanism by which some patients respond to fluoxetine while others do not remains poorly understood, limiting treatment effectiveness. We have found the opioid system to be involved in the responsiveness to fluoxetine treatment in a mouse model for anxiety- and depressive-like behavior.

Methods

We analyzed gene expression changes in the dentate gyrus of mice chronically treated with corticosterone and fluoxetine. After identifying a subset of genes of interest, we studied their expression patterns in relation to treatment responsiveness. We further characterized their expression through in situ hybridization and the analysis of a single-cell RNA sequencing dataset. F

SUBMITTER: Carazo-Arias E 

PROVIDER: S-EPMC10426813 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature